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Comments: 185 + -   Scientists Use Quake 2 To Study the Brains of Mice on Thursday October 15 2009, @02:10PM

Posted by Soulskill on Thursday October 15 2009, @02:10PM
from the god-help-us-if-they-learn-how-to-rocket-jump dept.
quake
games
science
An anonymous reader writes "In this week's issue of Nature, scientists from Princeton University trained mice to navigate around a virtual environment using a setup that resembles a combination of a giant trackball and a mini-iMax theater displaying a virtual world rendered using a modified version of the Quake 2 open source game engine. (Here's the academic paper, subscription required.) They hold the mouse's head still atop a giant trackball, which the mouse turns by running. The scientists use the rotations to move the mouse around in the virtual environment, and when he reaches certain places, he gets a reward. Because they are able to hold the head still, they can stick microscopic glass electrodes into individual neurons in the hippocampus of this mouse as it 'navigates.' They find the neural activity that resembles activity during real life navigation, and learned new things about the inputs and computations that are going on inside these neurons, which weren't known before. No word as of yet whether the scientists plan on giving the mice control of the gun. Wonder whether John Carmack ever envisioned this when he opened up the Quake code?"
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  • FP (Score:5, Funny)

    by CrazyJim1 (809850) * on Thursday October 15 2009, @02:10PM (#29760213) Journal
    Yo dawg, I heard you liked mice, so I put a mouse on your mouse.
  • Quake Fit? (Score:5, Funny)

    by natehoy (1608657) on Thursday October 15 2009, @02:12PM (#29760251) Journal

    If only we could do this with gamers who need exercise. They get a better immersive experience AND get fit at the same time.

    OK, so the open-brain surgery thing is going to be controversial, but...

  • Online play (Score:5, Funny)

    by Xebikr (591462) on Thursday October 15 2009, @02:14PM (#29760279)
    If I ever get fragged by a mouse, I hope no one ever tells me.
  • Damn! (Score:3, Funny)

    by mcgrew (92797) * on Thursday October 15 2009, @02:17PM (#29760321) Journal

    Fragged by a rodent! Damned thing was camping, too, the bastard.

    • Re:Damn! (Score:4, Interesting)

      by moogied (1175879) on Thursday October 15 2009, @02:20PM (#29760363)
      I'd be interested to see what would happen if they provided some kind of negative feedback to the mouse when a player shot it, and then just let them run rampant in there. I'd imagine mice would have a far better reaction rate then people in it.
      • I was thinking something along the same sort of lines; there's no force feedback (tactile feeback/negative feedback) for when he runs into stuff. I would like to see how the neuro-map for a mouse just being placed into the simulator looks compared to a mouse who spent his whole life "on the ball". I bet my brain's neuro-map looks a lot different when I'm playing TF2 compared to when I'm mountain biking or paintballing.

      • Re:Damn! (Score:5, Funny)

        by Miffe (592354) on Thursday October 15 2009, @02:41PM (#29760623)
        They need to hook it up to the device that gave mice orgasms at the push of a button, so that one frag is one orgasm. And then let them loose in quakelive.
      • Re:Damn! (Score:4, Interesting)

        by clone53421 (1310749) on Thursday October 15 2009, @02:44PM (#29760663) Journal

        Hmm, yeah, and they should train the mouse to fire the gun by rewarding it – first, make it find a target and operate the "gun firing" switch (whatever that is). Then train it to find a person and target them and "fire". Finally, put it up against armed opponents, give negative feedback if the mouse gets shot, and see what happens. Will the mouse go for positive feedback (by shooting opponents), will it hide/flee from the opponents (to escape the negative feedback it learns to associate with being shot by them), or will it be intelligent enough to create a new self-defense mechanism whereby it learns that by shooting the opponents before they can shoot it, it can both avoid the negative feedback and at the same time get positive feedback?

          • Re:Damn! (Score:5, Interesting)

            by clone53421 (1310749) on Thursday October 15 2009, @04:11PM (#29761687) Journal

            I suspect learning to use the in-game offense/defense mechanisms would tax the mouse's brain far beyond its capacity already without adding the complexity of choosing between different weapons.

            Although that does make me think of another interesting thing. Mice are more of a foraging creature... they look for food and hide from predators, fighting back only when cornered. A FPS, on the other hand, lends itself to predatory tactics... seeking your prey and killing them without being killed by their defensive tactics. Is it even possible for a mouse to learn to exhibit predatory behavior using a reward system, if their prey tendencies to flee or hide are being simultaneously triggered as their target fights back? If a bunch of mice were put into such a simulation, would they all hide from each other? Would they actively seek and kill each other? Or would there be some of both, where some mice tended to behave in a predatory manner (aggressive personalities?) while others hid (passive/survival)?

            • Re: (Score:3, Interesting)

              Mice are more of a foraging creature... they look for food and hide from predators, fighting back only when cornered. A FPS, on the other hand, lends itself to predatory tactics...

              The implication is that cats would be better FPS players than mice. The problem of course is that cats are sit-and-wait predators, sitting quietly and waiting for their prey to move before suddenly striking. In other words, campers. So playing on a server against a bunch of cats would probably suck. Dogs, which are pursuit predat

              • Re: (Score:3, Interesting)

                That's the key, though... what you described is exactly a "foraging" tactic. Find the lever, hit the lever, get the cheese.

                When the toon is able to interact with the mouse in a negative way (unpleasant) in addition to a positive way (pleasant), it's no longer just a maze or puzzle to solve. That's what would be so fascinating: would the mouse have the intelligence to plan and attempt to get the positive stimuli (reward) while avoiding the negative stimuli. (What you mentioned – the "target" is moving

  • Damn that would be awesome to have when playing Quake
  • Great. Now I have to worry about getting pwned by Frankie and Benjy.

  • mice or men (Score:5, Insightful)

    by ZenDragon (1205104) on Thursday October 15 2009, @02:20PM (#29760371)
    I invision an army of mice farming gold in World of Warcraft, we could do it even cheaper than the Chinese!
  • Oh great (Score:5, Funny)

    by davidbrit2 (775091) on Thursday October 15 2009, @02:21PM (#29760397) Homepage
    Catching mice that get in my house is enough of a pain, but now I have to snag the bastards while they're rocket jumping? Thanks, jerks.
  • by Satanboy (253169) on Thursday October 15 2009, @02:24PM (#29760431)

    This is a great example of open source really helping humanity learn new and interesting things.

    It's great to see that the tools provided by open software can really help speed up research.

    I wonder what would happen if old versions of adobe photoshop, 3ds max, or cubase were left to open source for research purposes. What kind of discoveries would scientists make with programs like these?

    • Re: (Score:3, Insightful)

      by Korin43 (881732)
      They'd discover that the total size of all bittorrent swarms has suddenly decreased ;)
      • by Chris Burke (6130) on Thursday October 15 2009, @07:37PM (#29764203) Homepage

        Seriously, what did they really learn from this?

        They learned about brain structure and relationships between cognition and motor control.

        You may not think that's worth it, but we've done a lot worse to mice than non-lethal brain surgery in order to learn a lot less.

        I wouldn't let anyone involved in this kind of experiment date my sister.

        *puts down bouquet of flowers, scalpel, and bundle of electrodes*

        Man, you're no fun.

  • Free information (Score:5, Insightful)

    by Dripdry (1062282) on Thursday October 15 2009, @02:24PM (#29760433) Journal

    Someone is likely to say it, so I will:

    This is what happens when you have a free flow of information. Carmack got well paid for Quake 2 then opened the source up (eventually). If more people/institutions/corps did this it seems there would not only be more hearts and flowers (for all the open source hippies) but there would be MORE technology we could patent! The ability to make MORE money!

    If I have 2 innovative products and I decide to open them up to general use, and at least 1 new idea comes from that, someone out there will create something with it and hopefully create a net gain for the system as a whole in the long run.

    I know people are selfish, but for Science's sake, open up your information already! The economy is dying a slow, painful death (though the market might refute that this week), wouldn't the SOLUTION in The States be to repeal some copyright laws and let information flow freely so as to foster innovation like this? Even if it's a mouse on a ball in a hall at the mall, I have to believe only good could come from opening things up a bit more.

  • by Jeremi (14640) on Thursday October 15 2009, @02:24PM (#29760441) Homepage
    1. Train mice on Quake 2 until they are really good at it
    2. Outfit mice with miniature rocket launchers and rail guns
    3. Turn the armed mice loose
    4. Rule the world!
  • by Saishuuheiki (1657565) on Thursday October 15 2009, @02:26PM (#29760461)
    Beats a console controller any day, even lab scientists agree
  • Frame rate? (Score:3, Interesting)

    by 192939495969798999 (58312) <infoNO@SPAMdevinmoore.com> on Thursday October 15 2009, @02:28PM (#29760491) Homepage Journal

    So what was the frame rate on the mouse's brain? Could it run crysis/linux?

  • No word as of yet whether the scientists plan on giving the mice control of the gun.

    ...they'll be training, I mean, "testing" sharks next.

  • by DieselPup (1657569) on Thursday October 15 2009, @02:39PM (#29760597)
    They initially tried this study using managers, but there was no evidence that the managers were learning anthing or that they even perceived their environment
  • by wowbagger (69688) on Thursday October 15 2009, @02:42PM (#29760641) Homepage Journal

    "Are you pondering what I am pondering, Pinky?"
    "I think so Brain, but how can I bunny-hop over the lava when I'm a mouse?"

  • Ideas (Score:3, Informative)

    by lymond01 (314120) on Thursday October 15 2009, @02:50PM (#29760705)

    No word as of yet whether the scientists plan on giving the mice control of the gun.

    Just whisper this when you say it. Rodents have unnaturally good hearing.

  • by reverseengineer (580922) on Thursday October 15 2009, @02:55PM (#29760787)
    The researchers originally wanted to use Half-Life instead of Quake 2, but they could never get the mice to do anything in the game other than murdering the scientists.
  • Rats (Score:5, Funny)

    by hoggoth (414195) on Thursday October 15 2009, @02:56PM (#29760789) Journal

    Just thought I'd point out that
    despite all my rage, I am still just a rat in a cage.

  • Acknowledgements (Score:3, Interesting)

    by interkin3tic (1469267) on Thursday October 15 2009, @03:08PM (#29760945)

    If anyone is wondering, the authors did thank Carmack and id software:

    Acknowledgements We thank E. Chaffin for help with mouse behaviour,
    J. Carmack and id Software for providing the Quake2 code

  • New definition (Score:3, Interesting)

    by SnarfQuest (469614) on Thursday October 15 2009, @03:12PM (#29761007)

    Gives you a new definition for a head mounted display.

  • by Darth_brooks (180756) <clipper377@ g m a i l . c om> on Thursday October 15 2009, @03:22PM (#29761115) Homepage

    I wondered why the last arena I logged in to had the quad damage replaced by a wheel of cheese, and why the rocket pickups were shaped like little smudges of peanut butter.

  • by Cycon (11899) <steve [at] theProfessionalAmateur.com> on Thursday October 15 2009, @06:39PM (#29763649) Homepage
    ...they need to hook up the screen to a camera feed from the flying beetles earlier this month. [newscientist.com]

    Let the mice steer the beetles!

  • by Samah (729132) on Friday October 16 2009, @12:30AM (#29765803)
    Konami presents: "Quake Quake Revolution", coming to a mouse-accessible game arcade near you!
    • Re: (Score:3, Funny)

      by aicrules (819392)
      I'll take a computer than runs Quake 2 at a reasonable 60 fps over a computer that takes millions of years to say "42".
You will be married within a year.