dryriver writes: I have been told that Linux can run Windows software using Wine or perhaps a VM. What happens if that Windows software is a GPU-computing application -- accessing the GPU through HLSL/GLSL/CUDA/OpenCL or similar interfaces? Can Wine or other solutions run that software at a decent speed under Linux? Or is GPU-computing software written for the Windows platform unsuitable for use -- emulated or otherwise -- under Linux? This sounds like one of those cases where there's a theoretical answer and then your own real-world experiences. So leave your best answers in the comments. Can Linux run a GPU-computing application that's written for Windows?